Please note that siRNA candidates produced by this wizard are not guaranteed to work. However, they do have a higher probability than randomly selected candidates.
1- Hornung V. et al.,2005. Sequence-specific potent induction of INF-α
by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 2005 Mar;11(3):263-70
2- Judge A. et al., 2005. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol. 2005 Apr;23(4):457-62
3- Lan T et al., 2009. Synthetic oligoribonucleotides-containing secondary structure acr a agonists of Toll-like receptors 7 and 8. Biochem Biophys Res Commun. [AOP]
This section allows you to select your own criteria to find a candidate siRNA sequence. We recommend that you choose your selection criteria following the siRNA design guidelines based on the results from various laboratories including ours.
InvivoGen provides a plasmid-based system developed to knockdown efficiently the expression of a wide variety of mammalian genes.
Our state-of-the-art facilities allow us to produce large quantities of high quality, endotoxin-free antibiotics with purity levels exceeding 95%.
The heart of InvivoGen's culture and commitment is to provide life scientists with quality and reliable reagents. Our strength in innovation comes from our expert scientific team that fosters the discovery and design of new tools and services to encourage cutting-edge bioresearch. As specialists in innate immunology, InvivoGen is a global leader of resources for the next breakthroughs in the field.
InvivoGen provides a set of cutting-edge tools to knockdown efficiently the expression of mammalian genes. These tools include the siRNA wizard software, shRNA cloning vectors and vectors expressing validated shRNAs, and systems for the prevalidation of siRNA/shRNAs or the detection of interferon response.
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