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WGP Soluble

WGP Soluble Unit size Cat. code Docs Qty Price
WGP control / Dectin-1 inhibitor
50 mg
tlrl-wgps
+-
$116.00

WGP control / Dectin-1 inhibitor - Whole Glucan Particles, soluble

WGP Soluble (WGP® Soluble, Biothera) is a pure soluble WGP preparation.

Similarly to particulate WGP, WGP Soluble binds efficiently Dectin-1, however it is incapable of activating the receptor [1].
Furthermore, WGP Soluble is able to significantly block the binding of WGP to macrophages and its immunostimulatory effect [2].

1. Goodridge HS. et al., 2011. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 472(7344):471-5.
2. Li B. et al., 2007. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin Immunol. 124(2):170-81.

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Specifications

Specificity: Dectin-1 inhibitor / WGP Dispersible control

Working concentration: 1 ng - 1 µg/ml

Endotoxin level: N/A

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Contents

50 mg WGP Soluble

WGP Soluble is shipped at room temperature.
Store at room temperature. Powder is stable 1 year when properly stored.

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Citations

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