WGP Soluble
| WGP Soluble | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
WGP control / Dectin-1 inhibitor |
50 mg |
tlrl-wgps |
WGP control / Dectin-1 inhibitor - Whole Glucan Particles, soluble
WGP Soluble (WGP® Soluble, Biothera) is a pure soluble WGP preparation.
Similarly to particulate WGP, WGP Soluble binds efficiently Dectin-1, however it is incapable of activating the receptor [1].
Furthermore, WGP Soluble is able to significantly block the binding of WGP to macrophages and its immunostimulatory effect [2].
1. Goodridge HS. et al., 2011. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 472(7344):471-5.
2. Li B. et al., 2007. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin Immunol. 124(2):170-81.
Specifications
Specificity: Dectin-1 inhibitor / WGP Dispersible control
Working concentration: 1 ng - 1 µg/ml
Endotoxin level: N/A
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50 mg WGP Soluble
WGP Soluble is shipped at room temperature.
Store at room temperature. Powder is stable 1 year when properly stored.