WGP Soluble
| WGP Soluble | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
Dectin-1b Antagonist / WGP control |
50 mg |
tlrl-wgps |
WGP control / Dectin-1b inhibitor - Whole Glucan Particles, soluble
WGP Soluble (WGP® Soluble, Biothera) is a pure soluble WGP preparation.
Similar to particulate WGP, WGP Soluble binds efficiently with Dectin-1b, however, it is incapable of activating this receptor [1].
Furthermore, WGP Soluble is able to significantly block the binding of WGP to macrophages and its immunostimulatory effect [2].
Read our review on Dectin-1 & β-glucans.
References:
1. Goodridge HS. et al., 2011. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 472(7344):471-5.
2. Li B. et al., 2007. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin Immunol. 124(2):170-81.
Specifications
Specificity: Dectin-1b inhibitor / WGP Dispersible control
Working concentration: 1 ng - 1 µg/ml
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Contents
- 50 mg WGP Soluble
WGP Soluble is shipped at room temperature.
Store at room temperature.
Powder is stable 1 year when properly stored.