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WGP Dispersible

WGP Dispersible Unit size Cat. code Docs Qty Price
Dectin-1 Agonist
50 mg
tlrl-wgp
+-
$116.00

Dectin-1 Agonist - Whole Glucan Particles, insoluble

WGP Dispersible (WGP® Dispersible, Biothera), whole glucan particles, is a particulate Saccharomyces cerevisiae β-glucan preparation.
It consists of hollow yeast cell wall “ghosts” composed primarily of long polymers of β-1,3 glucose obtained after a series of alkaline and acid extractions from S. cerevisiae cell wall [1].

In contrast to Zymosan, WGP lacks TLR-stimulating activity [2]. Similarly to Zymosan, WGP induces Dectin-1-dependent responses, including phagocytosis and induction of TNF-α, IL-6 and ROS by macrophages and dendritic cells.

1. Li B. et al., 2007. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin Immunol. 124(2):170-81.
2. Goodridge HS. et al., 2011. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 472(7344):471-5.

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Specifications

Specificity: Dectin-1 agonist

Working concentration: 1 - 200 µg/ml

Endotoxin level: N/A

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Contents

50 mg WGP Dispersible

WGP Dispersible is shipped at room temperature. Store at room temperature. Powder is stable 1 year when properly stored.

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Citations

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