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Triptolide

Triptolide Unit size Cat. code Docs Qty Price
NF-κB Inhibitor
1 mg
ant-tpl
+-
$90.00

NF-κB inhibitor

Triptolide, a diterpenoid isolated from Tripterygium wilfordii hook F, has been used for centuries in traditional Chinese medicine to treat immune-related disorders.

In addition to its anti-inflammatory and immunosuppressive activities, triptolide possesses potent antitumor properties. In a broad range of human tumor cells, Triptolide suppresses cell proliferation and induces apoptosis through caspase activation [1].

At a molecular level, Triptolide inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) [2], and by inhibiting the ATPase activity of XPB [3], a subunit of the general transcription factor TFIIH. 

Triptolide interferes with a number of transcription factors including p53 [4], NF-κB [5], nuclear factor of activated T-cells (NFAT) [5] and heat shock factor protein 1 (HSF-1) [6].

 

1. Carter BZ. et al., 2006. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 108: 630 - 637.
2. Wang Y. et al., 2011. Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II). PLoS One. 6(9):e23993.
3. Titov D. et al., 2011. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 7(3):182-8.
4. Chang, W.T. et al., 2001. Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway. J. Biol. Chem. 276, 2221–2227.
5. Qiu D. et al., 1999. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 274, 13443–13450.
6. Westerheide SD. et al., 2006. Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death. J. Biol. Chem., 281: 9616 - 9622.

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Specifications

Working concentration: 10 - 100 nM

CAS number: 38748-32-2

Molecular weight: 360.4

Solubility: DMSO, ethanol (10 mg/ml)

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Contents

  • 1 mg triptolide (white solid)

Triptolide is shipped at room temperature.

Store as supplied at -20°C in a tightly sealed vial.

Protect from light.

Triptolide as a solid is stable for 6 months when properly stored.

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Details

Triptolide chemical properties:

Triptolide chemical properties

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Citations

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