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Histone deacetylase inhibitor
Histone deacetylase Inhibitor
Trichostatin A (TSA), an antifungal antibiotic produced by Streptomyces hygroscopicus , is a potent and specific inhibitor of histone deacetylases (HDACs), which are overexpressed in various cancers and closely correlate with oncogenic factors.
Trichostatin A is active at nanomolar concentrations in mammalian cells. By suppressing the activity of HDACs, it leads to increased histone acetylation, thereby causing highly acetylated histones to accumulate in the cell . This in turn induces enhanced expression of specific genes that elicit extensive cellular morphologic and metabolic changes such as growth arrest, differentiation and apoptosis. At submicromolar concentrations Trichostatin A has been shown to induce apoptosis in diverse cancer cells while exhibiting very low toxicity to normal cells.
Interestingly, HDACs epigenetically silence transcription of the autophagy-related genes Atg and LC3. Thus, HDAC inhibitors like Trichostatin A and SAHA can lead to augmented levels of Atg and LC3 proteins and consequently, promote autophagy.
1. Tsuji N. et al., 1976. A new antifungal antibiotic, trichostatin. J Antibiot (Tokyo). 29(1):1-6.
2. Yoshida M. et al., 1990. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem. 265(28):17174-9.
CAS number: 58880-19-6
Molecular weight: 302.37
Solubility: DMSO (2 mg/ml)Back to the top
- 1 mg of Trichostatin A
Trichostatin A is shipped at room temperature.
Store at -20°C.Back to the top