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Trichostatin A

Trichostatin A Unit size Cat. code Docs Qty Price
Histone deacetylase inhibitor
1 mg
met-tsa-1
+-
$118.00

Histone deacetylase Inhibitor

Trichostatin A (TSA), an antifungal antibiotic produced by Streptomyces hygroscopicus [1], is a potent and specific inhibitor of histone deacetylases (HDACs), which are overexpressed in various cancers and closely correlate with oncogenic factors.

Trichostatin A is active at nanomolar concentrations in mammalian cells. By suppressing the activity of HDACs, it leads to increased histone acetylation, thereby causing highly acetylated histones to accumulate in the cell [2]. This in turn induces enhanced expression of specific genes that elicit extensive cellular morphologic and metabolic changes such as growth arrest, differentiation and apoptosis. At submicromolar concentrations Trichostatin A has been shown to induce apoptosis in diverse cancer cells while exhibiting very low toxicity to normal cells.

Interestingly, HDACs epigenetically silence transcription of the autophagy-related genes Atg and LC3. Thus, HDAC inhibitors like Trichostatin A and SAHA can lead to augmented levels of Atg and LC3 proteins and consequently, promote autophagy.

 

References:

1. Tsuji N. et al., 1976. A new antifungal antibiotic, trichostatin. J Antibiot (Tokyo). 29(1):1-6.
2. Yoshida M. et al., 1990. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem. 265(28):17174-9.

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Specifications

CAS number: 58880-19-6

Formula: C17H22N2O3

Molecular weight: 302.37

Solubility: DMSO (2 mg/ml)

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Contents

  • 1 mg of Trichostatin A

Trichostatin A is shipped at room temperature.

Store at -20°C.

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Citations

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