THP-1 TLR Cells
Engineered Human Reporter Monocytes
THP1 reporter cells are derived from THP-1, a human monocytic cell line that naturally expresses many pattern-recognition receptors, including Toll-like receptors.
InvivoGen offers several engineered THP-1 cell lines:
THP1-XBlue™ cells stably express an NF-κB/AP-1-inducible reporter (SEAP) system to facilitate the monitoring of TLR-induced NF-κB/AP-1 activation.
THP1 NF-κB cells were specifically designed for monitoring the NF-κB signal transduction pathway in a physiologically relevant cell line. They feature either the SEAP or the secreted luciferase (Lucia) reporter gene.