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SP600125

SP600125 Unit size Cat. code Docs Qty Price
JNK inhibitor
10 mg
tlrl-sp60
+-
$90.00

MAP Kinase Inhibitor - Autophagy Inhibitor - JNK inhibitor

SP600125 is a potent, cell-permeable, selective and reversible inhibitor of c-Jun N-terminal kinase (JNK) [1].

It inhibits in a dose-dependent manner the phosphorylation of JNK. JNK is a member of the mitogen-activated protein kinase (MAPK) family and plays an essential role in TLR mediated inflammatory responses [2, 3].

Inhibition of JNK activity by SP600125 is usually associated with downregulation of Beclin-1 and reduced autophagy.

 

1. Bennett Bl. et al., 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.Proc. Natl. Acad. Sci. USA. 98:13681-13686.
2. Kenzel S. 2006. c-Jun Kinase Is a Critical Signaling Molecule in a Neonatal Model of Group B Streptococcal Sepsis1. J Immunol. 176:3181-3188.
3. Adhikary G. et al., 2008. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J. Leukoc. Biol., 83: 991-997.

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Specifications

Working concentration: 10-50 µM

CAS number: 129-56-6

Synonym: SAPK inhibitor II

Molecular weight: 220.2

Solubility: 100 mM in DMSO and 10 mM in ethanol

Purity: >99% (HPLC)

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Contents

SP600125 is provided as a solid .

  • 10 mg

SP600125 is shipped at room temperature.

Store at -20 ̊C.

Solid product is stable 1 year at -20°C.

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Citations

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