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MAP Kinase Inhibitor - Autophagy Inhibitor - JNK inhibitor
SP600125 is a potent, cell-permeable, selective and reversible inhibitor of c-Jun N-terminal kinase (JNK) .
It inhibits in a dose-dependent manner the phosphorylation of JNK. JNK is a member of the mitogen-activated protein kinase (MAPK) family and plays an essential role in TLR mediated inflammatory responses [2, 3].
Inhibition of JNK activity by SP600125 is usually associated with downregulation of Beclin-1 and reduced autophagy.
1. Bennett Bl. et al., 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.Proc. Natl. Acad. Sci. USA. 98:13681-13686.
2. Kenzel S. 2006. c-Jun Kinase Is a Critical Signaling Molecule in a Neonatal Model of Group B Streptococcal Sepsis1. J Immunol. 176:3181-3188.
3. Adhikary G. et al., 2008. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J. Leukoc. Biol., 83: 991-997.
Working concentration: 10-50 µM
CAS number: 129-56-6
Synonym: SAPK inhibitor II
Molecular weight: 220.2
Solubility: 100 mM in DMSO and 10 mM in ethanol
Purity: >99% (HPLC)Back to the top
SP600125 is provided as a solid .
- 10 mg
SP600125 is shipped at room temperature.
Store at -20 ̊C.
Solid product is stable 1 year at -20°C.Back to the top