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IL-31 responsive STAT5-SEAP reporter assay

Signaling pathway in HEK-Blue™ IL-31 cells

InvivoGen also offers:

• Recombinant human IL-31
• Anti-hIL-31R (Nemolizumab)

HEK-Blue™ IL-31 cells are designed to monitor human IL-31-induced STAT5 stimulation or inhibition. This colorimetric bioassay can be used for screening activatory molecules, such as engineered cytokines, or inhibitory molecules, such as neutralizing antibodies.

HEK-Blue™ IL-31 cells respond specifically to recombinant human IL-31. The reliable and consistent performance of HEK-Blue™ IL-31 cells makes them suitable for release assays of therapeutic molecules that inhibit IL-31 signaling, such as Nemolizumab, a monoclonal antibody targeting the IL-31Rα subunit of the IL-31 receptor (see figures).

Key features

Readily assessable STAT5-SEAP reporter activity
Convenient readout using QUANTI-Blue™ Solution
High sensitivity to human (h) IL-31 activity
Stability guaranteed for 20 passages

Applications

Therapeutic development
Drug screening
Release assay

Interleukin-31 (IL-31) is a cytokine that plays a role in early protective inflammatory processes, likely regulating alarmins in damaged mucosal tissues. IL-31 is strongly involved in chronic inflammation in different skin diseases, including atopic dermatitis and allergic contact dermatitis.

More details

All InvivoGen products are for internal research use only, and not for human or veterinary use.

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