Invivogen
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SC79

SC79 Unit size Cat. code Docs Qty Price
Akt activator; autophagy inhibitor
10 mg
inh-sc79
+-
$150.00

SC79 is a selective and cell-permeable activator of Akt (also known as protein kinase B), a serine/threonine protein kinase signaling molecule with anti-apoptotic activity [1, 2]. The Akt kinase family comprises three highly homologous isoforms: Akt1 (PKBα), Akt2 (PKBβ) and Akt3 (PKBγ). SC79 potently activates all three isoforms and functions effectively in multiple cells types, including HeLa and HEK293 cells [2]. Interestingly, in animal models SC79 exhibits protective effects against the apoptotic and oxidative damage caused by ultraviolet radiation [1]. Moreover, this bloodbrain barrier permeable molecule displays neuroprotective properties in experimental stroke models possibly through its dual antiapoptotic and antioxidative activities [2, 3].

 

Gong YQ. et al., 2016. SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling. Oncotarget. 7(37):60123-60132.
Jo H. et al., 2012. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. PNAS 109(26):10581-6.
Zhang D. et al., 2016. Akt Specific Activator SC79 Protects against Early Brain Injury following Subarachnoid Hemorrhage. ACS Chem Neurosci. 2016;7:710–8.

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Specifications

Purity: ≥95% (UHPLC)

Solubility: 10 mg/ml (27.26 mM) in DMSO

CAS: 305834-79-1

Molecular weight: 366.8 g/mol

Formula: C17H19ClN2O5

Quality control: 

  • The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells. 
  • The inhibitory activity of the product has been validated using cellular assays.
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Contents

SC79 is provided lyophilized.

  • 10 mg

room temperature SC79 is shipped at room temperature.

store Store at -20 °C. Upon resuspension, prepare aliquots of SC79 and store at -20°C.

stable Resuspended SC79 is stable for 6 months when properly stored.

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Details

Structure of SC79

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