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TGF-β receptor inhibitor
Reprogramming Enhancer - TGF-β receptor inhibitor
SB431542 is a potent and selective inhibitor of transforming growth factor-β (TGF-β) superfamily type I activin receptor-like kinase (ALK) receptors, specifically ALK4, ALK5 and ALK7 .
Inhibition of TGF-β signaling is known to induce the de-repression of epithelial fate and thus was hypothesized to benefit the reprogramming process.
Indeed, treatment of OSKM-transduced human primary fibroblasts with a combination of SB431542 and PD0325901, a MEK inhibitor, was found to improve reprogramming efficiency of human cells .
1. Inman GJ. et al., 2002. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002 Jul;62(1):65-74.
2. Lin T. et al., 2009. A chemical platform for improved induction of human iPSCs. Nat Methods. 6(11):805-8.
Working concentration: 2 µM
Purity: >99% (HPLC)
CAS number: 301836-41-9
Molecular weight: 384.39
Solubility: approx. 20 mg/ml in DMSO or DMF. Approx. 2 mg/ml in ethanolBack to the top
SB431542 is provided as a crystalline solid.
- 5 mg SB431542
SB431542 is shipped at roomn temperature.
Store at -20 ̊C.
Solid product is stable 1 year at -20°C.Back to the top
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