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MAP Kinase Inhibitor
MAP Kinase Inhibitor - p38/RK MAP Kinase Inhibitor - Autophagy inducer
SB202190, a close relative of SB203580, is widely used to assess the physiological roles of p38α and p38β MAPKs.
Recent studies have identified other protein kinases, including GAK, CK1 and RIP2, that are potently inhibited by SB202190 (as well as SB203580) .
Further, SB202190 was shown to induce autophagic vacuoles through cross-inhibition of the PI3K/mTOR pathway .
1. Bain J. et al., 2007. The selectivity of protein kinase inhibitors: a further update. Biochem J. 408(3):297-315.
2. Menon MB. et al., 2011. SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. PLoS One. ;6(8):e23054.
Working concentration: 1-60 μM
CAS number: 152121-30-7
Molecular weight: 331.34
Solubility: 30 mg/ml in DMSO provides a yellow solution
Purity: >98% (UHPLC)Back to the top
- 5 mg SB202190 provided lyophilized
SB202190 is shipped at room temperature.
Store lyophilized product at -20°C.
Lyophilized product is stable for 1 year when properly stored.Back to the top