Resveratrol

NF-κB inhibitor - mTOR inhibitor - Autophagy inducer

Resveratrol (3,4',5-trihydroxy-trans-stilbene) is a polyphenol found in plants known to possess anti-inflammatory and chemopreventive properties.

Resveratrol has been shown to inhibit the expression of proinflammatory markers, including inducible nitric oxide synthase and cyclooxygenase-2 in macrophages and cancer cells [1], block TRIF-dependent signaling pathway of TLR3 and TLR4 [2] and modulate bacterial phagocytosis of macrophages [3].

Resveratrol may exert these diverse effects by suppressing NF-κB activation. Moreover, Resveratrol induces autophagy through its capacity to both inhibit mTOR and activate AMPK.

References:

1. Lorne E. et al., 2009. Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury. Am. J. Respir. Cell Mol. Biol. 41: 237 - 245.
2. Bhat, KP, Pezzuto JM., 2002. Cancer chemopreventive activity of resveratrol. Ann. NY Acad. Sci.957:210.-229.
3. Youn HS et al., 2005. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol. 175(5):3339-46.

Specifications

Working concentration: 10-100 μM (2.3 - 23 μg/ml)

CAS number: 501-36-0

Formula: C₁₄H₁₂O₃

Molecular weight: 228.24

Solubility: 20 mg/ml in DMSO

Purity: >98%

Contents

• 100 mg Resveratrol provided lyophilized

Resveratrol is shipped at room temperature.

Store lyophilized product at -20°C.

Product is stable for 1 year.