DC-SIGN (CD209)
| pUNO1-mDCSIGN | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
pUNO1 bearing the mouse DC-SIGN gene |
20 µg |
puno1-mdcsign |
Expression-ready ORF Clones
Dendritic cell-specific ICAM-3 grabbing nonintegrin
Alias : DCSIGN, CD209, CD209A, CDSIGN, DC-SIGN1, CLEC4L
DC-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIGN) is a C-type lectin involved in the capture of different pathogens.
DC-SIGN recognizes distinct carbohydrate structures such as the viral envelope glycoproteins expressed by the HIV1 [1], hepatitis C virus, and Ebola virus.
Non-viral pathogens can also interact with DC-SIGN including yeast, parasites and bacteria, such as Mycobacteria tuberculosis [2].
Following recognition, DC-SIGN internalizes the pathogens for processing and antigen presentation.
The central feature of the pathogens recognized by DC-SIGN is that they misuse DC-SIGN by distinct mechanisms that either circumvent antigen processing or alter TLR-mediated signaling, skewing T-cell responses [3].
References
1. Kwon DS. et al., 2002. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity. 16(1):135-44.
2. Appelmelk BJ. et al., 2003. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol. 170(4):1635-9.
3. Van Kooyk Y. & Geijtenbeek TB. 2003. DC-SIGN: escape mechanism for pathogens. Nat Rev Immunol. 3(9):697-709.
Specifications
Mouse DC-SIGN (pUNO1-mDCSIGN)
Genbank : NM_133238.5
ORF size : 717 bp
Subclone : AgeI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.