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DC-SIGN (CD209)

pUNO1-mDCSIGN Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse DC-SIGN gene
20 µg
puno1-mdcsign
+-
$384.00

Expression-ready ORF Clones

Dendritic cell-specific ICAM-3 grabbing nonintegrin

Alias : DCSIGN, CD209, CD209A, CDSIGN, DC-SIGN1, CLEC4L

 

DC-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIGN) is a C-type lectin involved in the capture of different pathogens.

DC-SIGN recognizes distinct carbohydrate structures such as the viral envelope glycoproteins expressed by the HIV1 [1], hepatitis C virus, and Ebola virus.

Non-viral pathogens can also interact with DC-SIGN including yeast, parasites and bacteria, such as Mycobacteria tuberculosis [2].

Following recognition, DC-SIGN internalizes the pathogens for processing and antigen presentation.

The central feature of the pathogens recognized by DC-SIGN is that they misuse DC-SIGN by distinct mechanisms that either circumvent antigen processing or alter TLR-mediated signaling, skewing T-cell responses [3].

 

References

1. Kwon DS. et al., 2002. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity. 16(1):135-44. 
2. Appelmelk BJ. et al., 2003. Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol. 170(4):1635-9. 
3. Van Kooyk Y. & Geijtenbeek TB. 2003. DC-SIGN: escape mechanism for pathogens. Nat Rev Immunol. 3(9):697-709. 

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Specifications

Mouse DC-SIGN (pUNO1-mDCSIGN)

Genbank : NM_133238.5
ORF size : 717 bp
Subclone : AgeI - NheI

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Contents pUNO1

  • 20 µg of lyophilized DNA
  • 2 x 1 ml blasticidin at 10 mg/ml

 

room temperature Product is shipped at room temperature.

store Lyophilized DNA should be stored at -20 ̊C.

stability Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.

Alert Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.

 

Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.

Avoid repeated freeze-thaw cycles.

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