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PI-103 is a potent ATP-competitive dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR (mammalian target of rapamycin).
PI3K, an important intracellular mediator, regulates multiple cellular functions including cell growth and survival. PI3K activates a number of downstream targets including the serine/threonine kinase Akt that activates mTOR, the master negative regulator of autophagy.
By inhibiting mTOR activity, PI‑103 induces autophagy and promotes cell survival [1, 2]. Conversely, combining PI‑103 with inhibitors of autophagy, such as 3-methyladenine or bafilomycin A1, leads to apoptosis .
1. Fan QW. & Weiss W., 2011. Autophagy and Akt promote survival in glioma. Autophagy7(5): 536-8.
2. Park S. et al., 2008. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.Leukemia. 22(9):1698-706.
Solubility: 10 mg/ml (28.7 mM) in DMSO
Synonym: 3-[4-(4-Morpholinylpyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
CAS number: 371935-74-9
Molecular weight: 348.5
Working Concentration: 0.1-10 μMBack to the top
PI-103 is provided as a solid.
- 5 mg PI-103
PI-103 is shipped at room temperature.
Store at -20 °C.Back to the top
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