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Perifosine

Perifosine Unit size Cat. code Docs Qty Price
Akt inhibitor
5 mg
tlrl-peri
+-
$124.00

Akt inhibitor - Autophagy inducer

Perifosine is an alkylphospholipid exhibiting antitumor activity. It induces cell cycle arrest and apoptosis through the inhibition of the serine-threonine protein kinase Akt (also known as protein kinase B) [1]. In addition, perifosine inhibits mTOR signaling through a different mechanism than classical mTOR inhibitors such as rapamycin [2].

Perifosine is the best characterized inhibitor of Akt. mTOR is a target for Akt, the activation of which suppresses autophagy. Therefore, treatment with perifosine, alone or in combination with rapamycin, induces autophagy.

 

1. HideshimaT. et al., 2006. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood. 107(10):4053-62.
2. Sun SY., 2010. Enhancing perifosine's anticancer efficacy by preventing autophagy. Autophagy. 6(1):184-5.

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Specifications

Synonym: KRX-0401

CAS number: 157716-52-4

Formula: C25H52NO4P

Molecular weight: 461.66

Solubility:
   -
50 mg/ml in water with warming
   - 200 mg/ml in ethanol

Purity: >99% (NMR)

Working concentration: 5 - 50 µM

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Contents

Perifosine is provided as a solid.

  • 5 mg Perifosine

Perifosine is shipped at room temperature.

Store at -20°C.

Solid product is stable 2 years at -20°C.

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