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MEK1 and MEK2 Inhibitor
MAPK Kinase Inhibitor - MEK1 and MEK2 Inhibitor
PD98059 is a potent and selective inhibitor of MAP kinase kinases (MAPKK), MEK1 and MEK2 . It binds to the inactive form of MAPKK and prevents activation by upstream activators such as c-Raf. Thus, PD98059 can be used to study the role of MAPKK signaling in different immune responses. For example, PD98059 can inhibit the lipopolysaccharide (LPS)-induced production of cytokines such as TNF-α [2, 3].
1. Alessi DR. et al., 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270, 27489-94.
2. Reiling N. et al., 2001. Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. J Immunol. 167:3339-45.
3. Guha M. et al., 2001. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood. 98(5):1429-39.
Working concentration: 10-100 μM
CAS number: 167869-21-8
Molecular weight: 267.28
Solubility: DMSO (6.5 mg/ml)
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