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PD0325901 [ Discontinued ]

PD0325901 Unit size Cat. code Docs Qty Price
MEK Inhibitor
2 mg
inh-pd32
+-
$150.00
discontinued

DISCONTINUED

Reprogramming Enhancer - MEK Inhibitor

PD0325901 is a synthetic organic molecule that selectively binds to and inhibits mitogen-activated protein kinase kinase (MEK).

The MEK/ERK signaling pathway plays an important role in the self-renewing state of ES cells [1].

Inhibition of this pathway combined with the inhibition of other signaling pathways has been shown to improve the efficiency of iPS cell generation.

Combination of PD0325901 with a TGF-β receptor inhibitor was found to improve the reprogramming of OSKM-infected human fibroblasts [2].

 

1. Ying QL. et al., 2008. The ground state of embryonic stem cell self-renewal. Nature. 453(7194):519-23.
2. Lin T. et al., 2009. A chemical platform for improved induction of human iPSCs. Nat Methods. 6(11):805-8.

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Specifications

Working concentration: 0.5 µM

CAS number: 391210-10-9

Purity: >98% (HPLC)

Molecular weight: 482.19

Solubility: DMSO, ethanol, DMF (20 mg/ml) 

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Contents

  • 2 mg PD0325901
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