DNA Vaccine Adjuvants
pBOOST plasmids were developed as genetic adjuvants for DNA vaccines to potentiate the immune response to a specific antigen. The method of plasmid DNA vaccine delivery is known to bias the immune response to a specific antigen towards a Th1 or Th2 response. These biases can be further enhanced by the codelivery of interferon regulatory factors (IRFs) or TANK-binding kinase 1 (TBK1) to increase the efficacy of the vaccination.
• pBOOST2 plasmids feature different IRFs for Th1 or Th2 polarization.
• pBOOST3 plasmid features TBK1 to enhance DNA vaccine immunogenicity.