DNA Vaccine Adjuvants

pBOOST plasmids were developed as genetic adjuvants for DNA vaccines to potentiate the immune response to a specific antigen.

The method of plasmid DNA vaccine delivery is known to bias the immune response to a specific antigen towards a Th1 or Th2 response.

These biases can be further enhanced by the codelivery of interferon regulatory factors (IRFs) or TANK-binding kinase 1 (TBK1) to increase the efficacy of the vaccination. Moreover, vaccination can be potentiated by the codelivery of genes encoding FLT3L and GM-CSF, two cytokines that support dendritic cell development.

  • pBOOST2 plasmids feature different IRFs for Th1 or Th2 polarization.
  • pBOOST3 plasmid features TBK1 to enhance DNA vaccine immunogenicity.
  • pBOOST4 plasmid features mouse FLT3L and GM-CSF to support dendritic cell development.
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