Parthenolide Unit size Cat. code Docs Qty Price
Caspase-1 and inflammasome inhibitor
50 mg

Caspase-1 and inflammasome inhibitor

Parthenolide, a sesquiterpene lactone derived from feverfew, is a known inhibitor of NF-κB activation.
It is also a direct inhibitor of caspase-1 and consequently of multiple inflammasomes, including the NLRP3 and NLRP1 inflammasomes [1].

Parthenolide has been found to block caspase-1 activation by alkylation of the p20 subunit. Further, parthenolide directly inhibits the NLRP3 inflammasome by interfering with NLRP3 ATPase activity.



1. Juliana C. et al., 2010. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 285(13):9792-802.
2. Zhang D. et al., 2009. Nuclear Factor-kB inhibition by parthenolide potentiates the efficacy of Taxol in Non–Small Cell Lung Cancer in vitro and in vivo. Mol. Cancer Res. 7:1139-49.

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Solubility: 50 mg/ml (202 mM) in DMSO or ethanol

CAS number: 20554-84-1

Formula: C15H20O3

Molecular weight: 248

Quality control:

  • Purity >95% (liquid chromatography).
  • The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
  • The inhibitory activity of the product is validated using the inflammasome inhibition assay.
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Parthenolide is provided lyophilized.

  • 50 mg Parthenolide

Parthenolide is shipped at room temperature.

Store at -20 °C.

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