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PAb-hTLR1

PAb-hTLR1 Unit size Cat. code Docs Qty Price
Human TLR1 Neutralizing antibody - Polyclonal Rat IgG
200 µg
pab-hstlr1
+-
$244.00

Human TLR1 Neutralizing antibody - Polyclonal Rat IgG

PAb hTLR1 is a polyclonal antibody specific for human Toll-like receptor 1 (TLR1, CD281).

PAb hTLR1 was generated by DNA vaccination. Wistar rats received four hydrodynamic injections of pVAC-hTLR1, a plasmid expressing the extracellular region of human TLR1. The sera were harvested and the IgG fraction purified by Protein G affinity chromatography.

The control for use with PAb-hTLR1 is PAb Control.

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Specifications

Clonality: Polyclonal antibody

Applications: Neutralizing human TLR1-induced cellular activation

Specificity: Human TLR1

Isotype: Rat IgG

Formulation: H2O with 250 U/ml Pen and 250 μg/ml Strep

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Contents

  • 200 μg polyclonal anti-hTLR1 antibody (PAb-hTLR1), provided sterile, azide-free and lyophilized

room temperature Product is shipped at room temperature.

store Lyophilized PAb-hTLR1 should be stored at -20°C.

stability Lyophilized product is stable for 6 months. Resuspended PAb-hTLR1 should be stored at 4°C for 1 month or -20°C for 3 months.

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Description

TLR1 is predominantly expressed in the spleen and peripheral blood cells. No direct ligands have been identified so far for TLR1, and its function remains unclear. TLR1 seems to act as a coreceptor for TLR2. TLR1 and TLR2 form heterodimeric complexes on the cell surface and in the cytosol [1]. TLR1 and TLR2 were shown to cooperate in recognizing Borrelia burgdorferi outer-surface protein A lipoprotein OspA [2]. They also interact to recognize the 19-kD mycobacterial lipopeptide and several synthetic triacylated lipopeptides [3], but not diacylated lipopeptides. This suggests that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration [4].

 

1. Sandor F. et al., 2003. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003 Sep 15;162(6):1099-110.
2. Alexopoulou L. et al., 2002. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 8(8):878-84.
3. Takeuchi O. et al., 2002. Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol, 169(1):10-4.
4. Takeuchi O. et al., 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol, 13(7):933-40.

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Citations

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