Class B CpG oligonucleotide - Murine TLR9 ligand
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs).
These CpG motifs are present at a 20-fold greater frequency in bacterial DNA compared to mammalian DNA.
CpG ODNs are recognized by Toll-like receptor 9 (TLR9) leading to strong immunostimulatory effects.
ODN 1668 is a CpG ODN class B specific for mouse TLR9. B-class CpG ODNs contain a full phosphorothioate backbone with one or more CpG dinucleotides.
They strongly activate B cells but weakly stimulate IFN-α secretion.