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AMPK activator - Autophagy inducer
AMPK Activator - mTOR Inhibitor - Autophagy inducer
Metformin activates adenosine monophosphate-activated protein kinase (AMPK), an enzyme that coordinates control of cell growth and autophagy. Metformin can be used to induce autophagy in an AMPK-dependent manner.
Metformin is used as an antidiabetic drug and displays significant growth inhibitory effects in several cancer models . Experimental data indicate that metformin blocks lymphoma cell growth through the inhibition of the mTOR pathway and the induction of autophagy .
1. Dowling R. et al., 2011. Understanding the benefit of metformin use in cancer treatment. BMC Medicine 9:33.
2. Shi W. et al., 2012. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis. 3:e275.
Synonym: Metformin hydrochloride
CAS number: 1115-70-4
Formula: C4H11N5, HCL
Molecular weight: 165.6 g/mol
Solubility: 100 mM in water
Working concentration: 2-10 mMBack to the top
Metformin is provided as a solid.
- 1 g Metformin
Metformin is shipped at room temperature.
Store at 4°C.
Solid product is stable 2 years when properly stored.Back to the top