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Metformin

Metformin Unit size Cat. code Docs Qty Price
AMPK activator - Autophagy inducer
1 g
tlrl-metf
+-
$75.00

AMPK Activator - mTOR Inhibitor - Autophagy inducer

Metformin activates adenosine monophosphate-activated protein kinase (AMPK), an enzyme that coordinates control of cell growth and autophagy. Metformin can be used to induce autophagy in an AMPK-dependent manner.

Metformin is used as an antidiabetic drug and displays significant growth inhibitory effects in several cancer models [1]. Experimental data indicate that metformin blocks lymphoma cell growth through the inhibition of the mTOR pathway and the induction of autophagy [2].

 

1. Dowling R. et al., 2011. Understanding the benefit of metformin use in cancer treatment. BMC Medicine 9:33.
2. Shi W. et al., 2012. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis. 3:e275.

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Specifications

Synonym: Metformin hydrochloride.

CAS number: 1115-70-4.

Formula: C4H11N5, HCL.

Molecular weight: 165.6.

Solubility: 100 mM in water.

Purity: >98%.

Working concentration: 2 - 10 mM.

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Contents

Metformin is provided as a solid.

  • 1 g Metformin

Metformin is shipped at room temperature.

Store at 4°C.

Solid product is stable 2 years when properly stored.

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