JAK/STAT Activation Inhibitors

Pathways of inhibition of JAK/STAT activation

The JAK/STAT pathway plays an important role in cytokine receptor-mediated signal transduction via activation of downstream signal transducers and activators of transcription (STAT), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) pathways.

These inhibitors are useful tools for exploring the contribution of JAK/STAT-mediated signaling.

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