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Isoliquiritigenin

Isoliquiritigenin Unit size Cat. code Docs Qty Price
NLRP3 inflammasome inhibitor
10 mg
inh-ilg
+-
$140.00

NLRP3 inflammasome inhibitor

Isoliquiritigenin (ILG), a simple chalcone-type flavonoid isolated from licorice root (Glycyrrhiza uralensis), exhibits anti-oxidant, anti‑inflammatory, and anti-tumor activities [1].

Isoliquiritigenin was recently reported to block LPS-induced TLR4/MD2 complex signaling and NF-kB activation [2], and to inhibit NLRP3-activated ASC oligomerization [3].

Interestingly, NLRP3-dependent IL-1β production has been inhibited with low concentrations of Isoliquiritigenin (1 to 10 µM). Thus, Isoliquiritigenin can block the NLRP3 inflammasome at both the priming step and the activation step.

 

References:

1. Jung SK. et al., 2014. Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wildtype and L858R/T790M Mutant EGFR. J Biol Chem. 289(52):35839-48.
2. Honda H. et al., 2012. Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol. 91(6):967-76.
3. Honda H. et al., 2014. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J Leukoc Biol. 96(6):1087-100.

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Specifications

Solubility: 50 mg/ml (195 mM) in DMSO or ethanol

CAS number: 961-29-5

Formula: C15H12O4

Molecular weight: 256

Quality control:

  • Purity >95% (liquid chromatography).
  • The absence of bacterial contamination (e.g. lipoproteins and endotoxins) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
  • The inhibitory activity of the product is validated using InvivoGen’s inflammasome inhibition assay
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Contents

Isoliquiritigenin is provided lyophilized.

  • 10 mg Isoliquiritigenin

Isoliquiritigenin is shipped at room temperature.

Store at -20˚C.

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