Isoliquiritigenin Unit size Cat. code Docs Qty Price
NLRP3 inflammasome inhibitor
10 mg

NLRP3 inflammasome inhibitor

Isoliquiritigenin (ILG), a simple chalcone-type flavonoid isolated from licorice root (Glycyrrhiza uralensis), exhibits anti-oxidant, anti‑inflammatory, and anti-tumor activities [1].

Isoliquiritigenin was recently reported to block LPS-induced TLR4/MD2 complex signaling and NF-kB activation [2], and to inhibit NLRP3-activated ASC oligomerization [3].

Interestingly, NLRP3-dependent IL-1β production has been inhibited with low concentrations of Isoliquiritigenin (1 to 10 µM). Thus, Isoliquiritigenin can block the NLRP3 inflammasome at both the priming step and the activation step.



1. Jung SK. et al., 2014. Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wildtype and L858R/T790M Mutant EGFR. J Biol Chem. 289(52):35839-48.
2. Honda H. et al., 2012. Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. J Leukoc Biol. 91(6):967-76.
3. Honda H. et al., 2014. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J Leukoc Biol. 96(6):1087-100.

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Solubility: 50 mg/ml (195 mM) in DMSO or ethanol

CAS number: 961-29-5

Formula: C15H12O4

Molecular weight: 256 g/mol

Quality control:

  • Purity >95% (liquid chromatography)
  • The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells
  • The inhibitory activity of the product has been validated using cellular assays
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Isoliquiritigenin is provided lyophilized.

  • 10 mg Isoliquiritigenin

Isoliquiritigenin is shipped at room temperature.

Store at -20˚C.

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Chemical structure of Isoliquiritigenin: 

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