H-89 Unit size Cat. code Docs Price
PKA inhibitor
5 mg

PKA inhibitor

H-89 is a selective, potent cell permeable inhibitor of cAMP-dependent protein kinase (PKA).

PKA is involved in the TLR-mediated TREM-1 expression on macrophages following LPS stimulation [1,2].

PKA inhibition with H-89 can also reduce IL-6 expression by 50% [3].



1. Hu J et al. 2002. Regulation of IL-1 Receptor-Associated Kinases by Lipopolysaccharide1 J. Immunol. 168: 3910-3914.
2. Murakami Y. et al., 2007. Lipopolysaccharide-Induced Up-Regulation of Triggering Receptor Expressed on Myeloid Cells-1 Expression on Macrophages Is Regulated by Endogenous Prostaglandin E2. J. Immunol. 178: 44.
3. Weigert C. et al., 2003. Microarray expression analysis of mesangial cells overexpressing glucose transporters: marked increase in interleukin-6 production. Nephrol. Dial. Transplant. 18: 32-44.

Back to the top


Working concentration: 5 - 50 µM

Purity: >99% (HPLC)

CAS number: 127243-85-0

Synonym: 5-isoquinolinesulfonamide, 2HCl

Formula:C20H20BrN3O2S 2HCl

Molecular weight: 519.3

Solubility: 50mg/ml in DMSO and ethanol, 25 mg/ml in H2O (heat to dissolve)

Back to the top


H-89 is provided as a solid.

  • 5 mg

H-89 is shipped at room temperature.

Store at -20 ̊C.

Solid product is stable 1 year at-20°C.

Back to the top
Customer Service
& Technical Support
Shopping cart is empty