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Proton pump inhibitor
NLRP3 Inflammasome Inhibitor - Proton pump inhibitor
Glybenclamide, also known as glyburide, is an ATP-sensitive potassium channel inhibitor.
It blocks the maturation of caspase-1 and pro-IL-1β by inhibiting the K+ efflux .
Glybenclamide has been shown to potently block the activation of the NRLP3 inflammasome induced by PAMPs, DAMPs and crystalline substances [2, 3].
Research suggests that this inhibitor works downstream of the P2X7 receptor but upstream of NRLP3 .
1. Laliberte RE. et al., 1999. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 274(52):36944-51.
2. Lamkanfi M. et al., 2009. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J. Cell Biol., 187: 61 - 70.
3. Dostert C. et al., 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One. 4(8):e6510.
Working concentration: 20-200 μg/ml
CAS Number: 10238-21-8
Molecular weight: 494 g/mol
Solubility: Soluble in DMSO (25 mg/ml) and ethanol (5 mg/ml)
- Purity ≥ 98% (UHPLC).
- The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ TLR2 and HEK‑Blue™ TLR4 cells.
- The inhibitory activity has been validated using cellular assays.
- 1 g of Glybenclamide (glyburide)
Product is shipped at room temperature.
Store at room temperature.
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