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Glybenclamide

Glybenclamide Unit size Cat. code Docs Qty Price
Proton pump inhibitor
1 g
tlrl-gly
+-
$72.00

NLRP3 Inflammasome Inhibitor - Proton pump inhibitor

Glybenclamide, also known as glyburide, blocks the maturation of caspase-1 and pro-IL-1β by inhibiting the K+ efflux [1].

Glybenclamide was shown to potently block the activation of the NRLP3 inflammasome induced by PAMPs, DAMPs and crystalline substances [2, 3].

Recent data suggest that glybenclamide works downstream of the P2X7 receptor but upstream of NRLP3 [2].

 

1. Laliberte RE. et al., 1999. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 274(52):36944-51.
2. Lamkanfi M. et al., 2009. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J. Cell Biol., 187: 61 - 70.
3. Dostert C. et al., 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One. 4(8):e6510.

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Specifications

Working concentration: 25 μg/ml

CAS Number: 10238-21-8

Purity: 98%

Molecular weight: 494

Solubility: Soluble in DMSO (25 mg/ml) and ethanol (5 mg/ml)

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Contents

Glybenclamide is provided as a white solid.

  • 1 g Glybenclamide (Glyburide

Glybenclamide is shipped at room temperature.

Store at room temperature.

Product is stable for 2 years.

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