Invivogen
Menu

Geldanamycin

Geldanamycin Unit size Cat. code Docs Qty Price
GA - HSP90 Inhibitor
5 mg
25 mg
ant-gl-5
+-
$116.00

An inhibitor of the heat-shock protein Hsp 90

Geldanamycin (GA) is a natural product produced by Streptomyces hygroscopicus.

InvivoGen produces GA from a mutant strain of S. hygroscopicus, inactivated for the synthesis of nigericin, a common contaminant of GA.

GA binds with high affinity into the ATP binding pocket of Hsp90. Hsp90 is a ubiquitous molecular chaperone critical for the folding, assembly and activity of multiple mutated and overexpressed signaling proteins that promote the growth and/or survival of tumor cells.
Hsp90 client proteins include mutated p53, Raf-1, Akt, ErbB2 and hypoxia-inducible factor 1a (HIF-1a) [1]. Binding of GA to Hsp90 causes the destabilization and degradation of its client proteins [2].

 

1. Neckers L., 2002. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8(4 Suppl):S55-61.
2. Whitesell L. et al., 1994. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. PNAS 91(18):8324-8.

Back to the top

Specifications

Working concentration: 1 nM - 10 μM

CAS number: 30562-34-6

Formula: C29H40N2O9

Molecular weight: 560

Solubility: Soluble in DMSO (1 mg/ml)

Back to the top

Contents

  • 5 mg or 25 mg

room temperature Geldanamycin is shipped at room temperature.

store Store product at -20°C.

Alert Protect from light.

stable Product in powder form is stable for 6 months when stored properly

Back to the top

Citations

Load more

Customer Service
& Technical Support

CAPTCHA
In order to prevent automated spam submissions, please answer the following question:
12 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Shopping cart is empty