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GA - HSP90 Inhibitor
An inhibitor of the heat-shock protein Hsp 90
Geldanamycin (GA) is a natural product produced by Streptomyces hygroscopicus.
InvivoGen produces GA from a mutant strain of S. hygroscopicus, inactivated for the synthesis of nigericin, a common contaminant of GA.
GA binds with high affinity into the ATP binding pocket of Hsp90. Hsp90 is a ubiquitous molecular chaperone critical for the folding, assembly and activity of multiple mutated and overexpressed signaling proteins that promote the growth and/or survival of tumor cells.
Hsp90 client proteins include mutated p53, Raf-1, Akt, ErbB2 and hypoxia-inducible factor 1a (HIF-1a) . Binding of GA to Hsp90 causes the destabilization and degradation of its client proteins .
1. Neckers L., 2002. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8(4 Suppl):S55-61.
2. Whitesell L. et al., 1994. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. PNAS 91(18):8324-8.
Working concentration: 1 nM - 10 μM
CAS number: 30562-34-6
Molecular weight: 560
Solubility: Soluble in DMSO (1 mg/ml)Back to the top
- 5 mg or 25 mg
Geldanamycin is shipped at room temperature.
Store product at -20°C.
Protect from light.
Product in powder form is stable for 6 months when stored properlyBack to the top