Invivogen
Menu

Gardiquimod VacciGrade™

Gardiquimod VacciGrade™ Unit size Cat. code Docs Qty Price
Imidazoquinoline compound -TLR7 agonist
5 mg
vac-gdq
+-
$558.00

Imidazoquinoline compound

Gardiquimod is an imidazoquinoline compound developed and manufactured by InvivoGen. This imidazoquinoline compound is a guanosine derivative and agonist for TLR7. Gardiquimod™ is an effective adjuvant by activating dendritic cells (DCs) and B cells to induce cytokines optimal for Th1 cell immunity, and antibody production.

Gardiquimod™ VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile and thoroughly tested for the presence of endotoxins.

Gardiquimod™ VacciGrade™ is for research use only, not for use in humans.

Back to the top

Specifications

Specificity: Th1 response

Working concentration: 10- 100 μg/mouse

Quality: Sterile, Endotoxin level <5 EU/mg

CAS number: 1020412-43-4

Solubility: 1 mg/ml in physiological water

Quality control:

  • Gardiquimod™ VacciGrade™ is a preclinical grade preparation of Gardiquimod™ .
  • It is prepared under strict aseptic conditions and is tested for the presence of endotoxins.
  • Gardiquimod™ VacciGrade™ is guaranteed sterile and its endotoxin level is <5 EU/mg.
Back to the top

Contents

  • 5 mg of sterile lyophilized Gardiquimod VacciGrade™
  • 10 ml sterile endotoxin-free physiological water (NaCl 0.9%)

room temperature Gardiquimod VacciGrade™ is shipped at room temperature

storeStored at -20°C.

stable Lyophilized product is stable for 1 year when properly stored.

Upon resuspension, prepare aliquots of Gardiiquimod VacciGrade™ and store at -20°C.

Resuspended product is stable for 6 months when properly stored. Avoid repeated freeze-thaw cycles.

Back to the top

Description

Gardiquimod™ is a imidazoquinoline compound developed and manufactured by InvivoGen.

Similarly to Imiquimod, Gardiquimod™ induces the activation of NF-κB in HEK293 cells expressing human or mouse TLR7.

In vitro models of vaccination indicate that Gardiquimod™ is a strong immunostimulant inducing cytokine production and the generation of dendritic cells [1].

Experimental models demonstrated that Gardiquimod™ can induce strong cellular responses and has potential as an adjuvant for cancer therapy [2, 3].

Furthermore, Gardiquimod™ can induce mucosal responses that are superior to R848 and comparable to those induced by the established mucosal adjuvant cholera toxin [4].

 

1. Ma Y et al., 2007. In vitro vaccination site: a novel test bed for immunopotentiators. J Immunol. 178, S18.
2 Ma F. et al., 2010. The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cellular & Molecular Immunology 7, 381-388.
3. Cho HI & Celis E., 2009. Optimized Peptide Vaccines Eliciting Extensive CD8 T-Cell Responses with Therapeutic Antitumor Effects. Cancer Res. 69(23):9012-9.
4. Velasquez LS. et al., 2010. An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles. Clin Vaccine Immunol. 17(12):1850-8.

Back to the top

Customer Service
& Technical Support

Shopping cart is empty