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FITC-Geldanamycin

FITC-Geldanamycin Unit size Cat. code Docs Qty Price
FITC-labeled geldanamycin
1 mg
5 mg
ant-fgl-1
+-
$215.00

FITC-labeled geldanamycin

FITC-geldanamycin is a fluorescent derivative of geldanamycin. The fluorescein-5-isothiocyanate dye is linked to geldanamycin at the C17 position [1].

FITC-geldanamycin binds tightly to Hsp90. This interaction can be competed by Hsp90 inhibitors such as 17-AAG.

Therefore, FITC-geldanamycin can be used to screen for new Hsp90 inhibitors by measuring its binding to Hsp90 through a fluorescent polarization assay.

 

1. Llauger-bufi L. et al., 2003. Synthesis of novel fluorescent probes for the molecular chaperone Hsp90. Bioorg Med Chem Lett. 13(22):3975-8.

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Specifications

Formula: C64H79N7O15S

Molecular weight: 1218.43

Solubility: DMSO (10 mg/ml)

Working concentration: 1 nM - 10 μM

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Contents

FITC-Geldanamycin is provided lyophilized and is supplied in two pack sizes:

  • 1 mg: ant-fgl-1
  • 5 mg: ant-fgl-5

room temperature FITC-Geldanamycin is shipped at room temperature.

store Store at -20°C.

Alert Protect from light.

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Citations

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