|FITC-Geldanamycin||Unit size||Cat. code||Docs||Qty||Price|
FITC-geldanamycin is a fluorescent derivative of geldanamycin. The fluorescein-5-isothiocyanate dye is linked to geldanamycin at the C17 position .
FITC-geldanamycin binds tightly to Hsp90. This interaction can be competed by Hsp90 inhibitors such as 17-AAG.
Therefore, FITC-geldanamycin can be used to screen for new Hsp90 inhibitors by measuring its binding to Hsp90 through a fluorescent polarization assay.
1. Llauger-bufi L. et al., 2003. Synthesis of novel fluorescent probes for the molecular chaperone Hsp90. Bioorg Med Chem Lett. 13(22):3975-8.
Molecular weight: 1218.43
Solubility: DMSO (10 mg/ml)
Working concentration: 1 nM - 10 μMBack to the top
FITC-Geldanamycin is provided lyophilized and is supplied in two pack sizes:
- 1 mg: ant-fgl-1
- 5 mg: ant-fgl-5
FITC-Geldanamycin is shipped at room temperature.
Store at -20°C.
Protect from light.Back to the top