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Everolimus

Everolimus Unit size Cat. code Docs Qty Price
mTOR inhibitor - Autophagy Inducer
5 mg
tlrl-eve
+-
$80.00

mTOR inhibitor - Autophagy Inducer

Everolimus (RAD001), a derivative of rapamycin, is an inhibitor of mTOR. mTOR is a key downstream protein kinase of PI3K/AKT signaling pathway, and plays a central role in controlling cancer cell growth.

Everolimus is currently used as an immunosuppressant to prevent the rejection of organ transplants and for the treatment of certain types of cancer [1].

 It has been demonstrated that in cancer models Everolimus promotes autophagy through the inhibition of mTOR [2].

 

1. Chiong E. et al., 2011. Effects of mTOR inhibitor everolimus (RAD001) on bladder cancer cells. Clin Cancer Res. 17(9):2863-73.
2. Crazzolara R. et al., 2009. Everolimus induces autophagy in acute lymphoblastic leukemia. Autophagy. 5(5):727-8.

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Specifications

Synonym: RAD001.

CAS number: 159351-69-6.

Formula: C53H83NO14.

Molecular weight: 958.22.

Solubility: 10 mg/ml in DMSO.

Purity: ≥98%.

Working concentration: 1 - 300 nM.

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Contents

Everolimus is provided as a translucent film.

  • 5 mg Everolimus

Everolimus is shipped at room temperature

Store at -20°C.

Solid product is stable for 2 years whenproperly stored.

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Citations

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