Dominant Negative Genes

InvivoGen has engineered TLR genes deleted for the TIR domain (TLR-ΔTIR) that act as dominant negatives.

Dominant negative (DN) forms of other TLR related genes (such as TLR signaling genes) were created by inserting a mutation within the gene and/or deleting a region of the gene. These modifications have been described elsewhere  and shown to block the wildtype form of these genes.

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