|Cyclosporin A||Unit size||Cat. code||Docs||Price|
Cyclopsporin A is a calcineurin inhibitor that exerts its immunosuppressive effects through the down-regulation of NFAT (nuclear factor of activated T cells) transcription factor, thus preventing the transcription of T cell effector cytokines .
Moreover, NFAT has been implicated in the downstream signaling of Dectin-1 which is important in the innate immune response against fungal infection .
Conversely, it has been demonstrated that inhibition of calcineurin in macrophages enhances NF-κB activation  and can trigger TLR signaling by activating both the MyD88-dependent and the MyD88-independent pathways .
1. Chow CW. et al., 1999. Requirement for transcription factor NFAT in interleukin-2 expression. Mol Cell Biol. 19(3): 2300-07.
2. Goodridge et al. 2007. Dectin-1stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol. 178( 5): 3107-15.
3. Asai T. et al., 2003. Activation of transcription factors AP-1 and NF-κB in chronic cyclosporine A nephrotoxicity: role in beneficial effects of magnesium supplementation. Transplantation 75(7):1040–4.
4. Kang Y. et al., 2007. Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol 179(7):4598–607.
Working concentration: 50 nM - 1.5 μM
CAS number: 59865-13-3
Solubility: DMSO (50 mg/ml)
Molecular weight: 1202.61Back to the top
Cyclosporin A is provided as a solid
- 100 mg Cyclosporin A
Cyclosporin A is shipped at room temperature.
Store at -20°C.
Solid product is stable 1 year at -20°C when properly stored.
Upon resuspension, Cyclosporin A should be aliquoted and stored at -20°C.
Protect from light.
Avoid repeated freeze-thaw cycles.
Resuspended product is stable 3 months at -20°C when properly stored.