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Chitosan Ultrapure

Chitosan Ultrapure Unit size Cat. code Docs Qty Price
NLRP3 Inflammasome Inducer - Deacetylated derivative of chitin
100 mg
tlrl-cht
+-
$124.00

NLRP3 Inflammasome Inducer - Deacetylated derivative of chitin

Chitosan is the deacetylated derivative of chitin, a polysaccharide found in the exoskeletons of crustaceans and in the cell walls of fungi.

Chitosan is well known for its use in drug delivery, where it is used to enhance the absorption of proteins across mucosal surfaces.
In addition to its role in drug delivery, chitosan is an immunostimulator [1]: it activates the NLRP3 inflammasome, leading to potent IL-1β production [2, 3]. Chitosan is of interest for immunotherapy and vaccination due to its immunomodulatory effects.

InvivoGen provides an ultra-pure chitosan of non-animal origin, purified from white edible mushrooms (Agaricus bisporus), that has been formulated to increase its solubility.

1. Lin Y. et al., 2014. Chitosan as an adjuvant-like substrate for dendritic cell culture to enhance antitumor effects. Biomaterials. 35(31):8867-75.
2. Neumann S. et al, 2014. Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunol Cell Biol. 92:535-42
3. Bueter C. et al., 2011. Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. J Biol Chem. 286(41):35447-55.

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Specifications

Synonym: Poly(D-glucosamine); Deacetylated chitin
CAS number: 9012-76-4
Molecular weight: 60 - 120 kDa
Degree of acetylation (%mol): 15-25
Working concentration:
10-100 µg/ml
Quality control:

- The biological activity of chitosan is confirmed using the inflammasome induction assay based on THP1-Null cells and HEK‑Blue™ IL-1β cells.
- The absence of bacterial contamination (e.g. endotoxins and peptidoglycans) is confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.

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Contents

• 100 mg Chitosan Ultrapure
• 10 ml endotoxin-free water containing 1% acetic acid
• 10 ml endotoxin-free water

Chitosan Ultrapure is provided lyophilized and shipped at room temperature.
Store at 2-8 °C.

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Details

Chitosan Structure

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