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Celastrol, a quinone methide triterpene isolated from the Chinese medicinal plant Tripterygium wilfordii, is known for its antitumor and anti-inflammatory properties but its mode of action and spectrum of cellular targets are poorly understood.
Celastrol was recently found to be a potent inhibitor of the heat-shock protein Hsp90 inducing the disruption of protein-protein interactions of Hsp90 and its co-chaperones [1,2].
Furthermore, it was shown to act as an effective inhibitor of the transcription factor NF-κB potentiating the apoptosis induced by TNF-α and chemotherapeutic agents and inhibiting invasion .
1. Zhang T. et al., 2008. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther., 7: 162-170.
2. Hieronymus H. et al., 2006. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell, 10(4): 321-330.
3. Sethi G. et al., 2007. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood, 109: 2727-2735.
Working concentration: 300 nM-10 μM
Endotoxin levels: CAS number: 34157-83-0
Molecular weight: 450.6
Solubility: 10 mg/ml in DMSOBack to the top
- 1 mg
Celastrol is shipped at room temperature.
Store as supplied at -20°C in a tightly sealed vial.Back to the top