Invivogen
Menu

c-di-UMP

c-di-UMP Unit size Cat. code Docs Qty Price
STING agonist negative control
1 mg
tlrl-nacdu
+-
$169.00

STING agonist negative control

Cyclic di-uridine monophosphate (c-di-UMP) is a synthetic cyclic dinucleotide containing a pyrimidine base.

Unlike the purine-containing cyclic dinucleotides (c-di-AMP, c-di-GMP and c-di-IMP), c-di-UMP is not predicted to bind strongly to STING [1]. The smaller size of the pyrimidine base is expected to prevent the formation of stacking interactions that are crtitical for proper binding to STING.

Indeed, STING-expressing cells, such as THP1-Blue™ ISG cells, do not respond to c-di-UMP, even at high concentrations.

 

1. Yin Q. et al., 2012. Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 46(6):735-45.

Back to the top

Specifications

Description: STING agonist negative control

Synonym: Cyclic di-uridine monophosphate, c-di-UMP sodium salt

CAS number: 73120-97-5

Formula: C18H20N4O16P2 .2Na

Molecular weight: 656.3

Purity: ≥ 95% by LC/MS

Solubility: 50 mg/ml in water

Quality control:

  • The inability of c-di-UMP to induce the STING/TBK1/IRF3 pathway has been confirmed in THP1-Blue™ ISG cells.
  • The absence of endotoxins and other bacterial contaminants has been confirmed using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.

 

Back to the top

Contents

  • 1 mg lyophilized c-di-UMP
  • 1.5 ml endotoxin-free water

room temperature Product is shipped at room temperature

store Stored at -20°C.

Product is sterile filtered prior to lyophilization.

Back to the top

Citations

Load more

Customer Service
& Technical Support

CAPTCHA
In order to prevent automated spam submissions, please answer the following question:
7 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Shopping cart is empty