InvivoGen provides a collection of monoclonal antibodies targeting human Toll-like receptor 3 (TLR3). TLR3 recognizes double-stranded RNA (dsRNA), a molecular pattern associated with viral infection.
Stimulation with poly(I:C), a synthetic analog of dsRNA, was shown to induce hyporesponsiveness in TLR3-deficient mice and considerable responsiveness in HEK293 cells expressing TLR3 , suggesting a specific recognition to poly(I:C) by TLR3.
TLR3 signals mainly through a MyD88-independent pathway involving the TRIF/TICAM1 adapter protein that leads to the production of IFN-β and causes dendritic cells to mature .
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2. Yamamoto m. et al. 2002. Cutting edge: A novel Toll/Il-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J Immunol, 169(12):6668-6672.