InvivoGen provides a collection of monoclonal and polyclonal antibodies targeting human Toll-like receptor 1 (TLR1) for neutralization and detection.
TLR1 is predominantly expressed in the spleen and peripheral blood cells. No direct ligands have been identified so far for TLR1, and its function remains unclear. TLR1 seems to act as a coreceptor for TLR2.
TLR1 and TLR2 form heterodimeric complexes on the cell surface and in the cytosol . TLR1 and TLR2 were shown to cooperate in recognizing Borrelia burgdorferi outer-surface protein A lipoprotein OspA .
They also interact to recognize the 19-kD mycobacterial lipopeptide and several synthetic triacylated lipopeptides , but not diacylated lipopeptides.
This suggests that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration .
1. Sandor F. et al., 2003. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003 Sep 15;162(6):1099-110.
2. Alexopoulou L. et al., 2002. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 8(8):878-84.
3. Takeuchi O. et al., 2002. Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol, 169(1):10-4.
4. Takeuchi O. et al., 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol, 13(7):933-40.