InvivoGen provides monoclonal antibodies targeting human IL-18 for neutralization and detection.
Interleukin 18 (IL-18; formerly called interferon-γ inducing factor) is a pro-inflammatory cytokine that causes a wide variety of biological effects associated with infection, inflammation and autoimmune processes [1, 2].
More specifically, IL-18 induces IFN-γ production and contributes to T-helper 1 (Th1) cell polarization.
IL-18 is produced by macrophages and other cells, as a proprotein which is proteolytically processed to its active form by caspase 1, an enzyme that is activated within the inflammasome multiprotein complex.
IL-18 binds to an heterodimeric receptor consisting of IL-18R and IL-18 receptor accessory protein (IL-18RAP).
Upon binding, IL-18 activates NF-κB and AP-1 via signaling pathways that involve IRAK and TRAF-6 [3, 4].
Arend W. et al., 2008. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev. 223:20-38.
Dinarello CA. et al., 1998. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol. 63(6):658-64.
Gracie JA. et al., 2003. Interleukin-18. J Leukoc Biol.3(2):213-24.
Kojima H. et al., 1998. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. BBRC 244(1):183-6.