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Anti-IFN-α

InvivoGen provides a collection of monoclonal antibodies targeting human interferons alpha for neutralization and detection.

Interferon-alpha (IFN-α) is a type I interferon that has both anti-viral and immunomodulatory activities [1]. IFN-α is produced primarily by plasmacytoid dendritic cells [2]. Thirteen different IFN-α subtypes have been described. Although the reason for the multiple IFN-α subtypes is not fully understood, evidence suggests that they have distinct functions [3].

 

Trinchieri G., 2010. Type I interferon: friend or foe? JEM 207(10):2053-2063.
Ivashkiv LB. & Donlin LT., 2014. Regulation of type I interferon responses. Nat Rev Immunol. 14(1):36-49.
Gibbert K. et al., 2013. IFN-α subtypes: distinct biological activities in anti-viral therapy. Br J Pharmacol. 168(5):1048-58.

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