|Anti-hTNF-α-mIgG2a||Unit size||Cat. code||Docs||Qty||Price|
Neutralizing murine IgG2a monoclonal antibody against human TNF-α
Anti-hTNF-α-mIgG2a is a neutralizing monoclonal antibody featuring the constant region of the murine IgG2a isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-mIgG2a was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G. The neutralizing activity of this murine IgG2a antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Mouse IgG2a
100 µg purified anti-hTNFα-mIgG2a antibody, provided azide-free and lyophilizedBack to the top