|Anti-hTNF-α-hIgM||Unit size||Cat. code||Docs||Qty||Price|
Neutralizing human IgM monoclonal antibody against human TNF-α
Anti-hTNF-α-hIgM is a neutralizing monoclonal antibody featuring the constant region of the human IgM isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgM was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein L. The neutralizing activity of this human IgM antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgM
100 µg purified anti-hTNFα-hIgM antibody, provided azide-free and lyophilizedBack to the top