CD20 is a transmembrane phosphoprotein that is expressed on the surface of B lymphocytes.

The CD20 antigen is present on both resting and activated B lymphocytes but is lost prior to differentiation into plasma cells.

As CD20 expression is restricted to B cells, this antigen is a useful marker or target for B-cell lymphomas.

Studies demonstrate that the expression of CD20 correlates with B-cell lymphoma in dogs.

In human medicine, an anti-human CD20 monoclonal antibody (Rituximab) has been approved by the FDA to treat B-cell non-Hodgkin's lymphoma resistant to other chemotherapy regimens.

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