Antibodies against human CD14
CD14 is a glycosylphosphatidylinositol (GPI)-anchored membrane protein which acts as a bacterial pattern recognition receptor .
CD14 is found on cells derived from the monocyte/macrophage lineage, as well as neutrophils and B lymphocytes.
CD14 serves as a member of the heteromeric lipopolysaccharide (LPS) receptor complex that also contains TLR4 and MD2 .
CD14 binds LPS but is not capable of initiating a transmembrane activation signal since it does not contain a cytoplasmic domain.
Upon LPS binding, CD14 physically associates with TLR4 which in turn transduces the signal. CD14 was also shown to interact with TLR2 in response to various microbial infections .
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