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AG490 is a specific and potent inhibitor of the Janus kinase 2 protein (JAK2) . JAK2 regulates the phosphorylation of JNK, primarily through PI3K. It has been established that JAK2 plays an important role in TLR-mediated biological responses, blocking TLR4-mediated responses to LPS [2,3] and TLR5-mediated responses to flagellin . JAK2 is also involved in cytokine signaling, such as IL-2, IL-6 and IL-12.
1. Levitzki A. 1990. Tyrphostins- potential antiprolierative agents and novel molecular tools. Biochem. Pharmacol. 40:913-918.
2. Okugawa S. et al., 2003. Janus kinase 2 is involved in lipopolysaccaride-induced activation of macrophages. Am. J. Physiol. Cell Physiol. 285: C399-C408.
3. Kimura A et al. 2005. Suppressor of cytokine signaling-1 selectively inhibits LPSinduced IL-6 production by regulating JAK–STAT. PNAS 102:17089-17094
4. Ha H et al. 2008. Stimulation by TLR5 Modulates Osteoclast Differentiation through STAT1/IFN-β1. J. Immuno.180:1382-1389.
Working concentration: 20-50 µM
Purity: ≥99% (UHPLC)
CAS number: 133550-30-8
Synonym: Tyrphostin B42
Molecular weight: 294.3
Solubility: 50 mg/ml in DMSO and 5 mg/ml in ethanolBack to the top
AG490 is provided lyophilized.
- 10 mg AG490
AG490 is shipped at room temperature.
Store at -20 °C.Back to the top