Invivogen
Menu

A-769662 [ Discontinued ]

A-769662 Unit size Cat. code Docs Qty Price
AMPK Activator (mTOR Inhibitor)
10 mg
inh-a769
+-
$176.00
discontinued

DISCONTINUED

AMPK Activator (mTOR Inhibitor)

A-769662 is a potent and reversible activator of AMPK (AMP-activated protein kinase), an energy sensing serine/threonine protein kinase important in cellular metabolism [1].

Through the activation of AMPK, A-769662 inhibits mammalian target of rapamycin (mTOR), an enzyme in the PI3K/AKT/mTOR intracellular signalling pathway that plays a central role in cell proliferation, growth, and survival [2].

Studies demonstrate that A-769662 inhibits cell proliferation of various cell types [3, 4].

In addition to its role in cell metabolism and proliferation, A-769662 is also considered as an anti-inflammatory agent as it reduces the activation of JNK, a member of the mitogen-activated protein kinase (MAPK) family that plays an essential role in inflammatory responses [5, 6].

 

Göransson O. et al., 2007. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 282(45):32549-60.
van der Heijden M. & Bernards R., 2010. Inhibition of the PI3K pathway: Hope we can believe in? Clin Cancer Res. 16(12):3094-9.
de Meester C. et al., 2013. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.
Peyton K. et al., 2012. Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells. J Pharmacol Exp Ther. 342(3):827-34
Dandapani M. & Hardie DG., 2013. AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells? Biochem Soc Trans. 41(2): 687–693.
Galic S. et al., 2011. Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J. Clin. Invest.121(12):4903–4915

Back to the top

Specifications

Working Concentration: 100 -300 μM

CAS number: 844499-71-4

Synonym: 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Formula: C20H12N2O3S

Molecular weight: 360.39

Solubility: DMSO (30 mg/ml)

Purity: >98% (UHPLC)

Quality control:

Back to the top

Contents

A-769662 is provided as a solid.

  • 10 mg A-769662

A-769662 is shipped at room temperature.

Store at -20°C.

Solid product is stable at least 1 year at -20°C.

Back to the top

Customer Service
& Technical Support

CAPTCHA
In order to prevent automated spam submissions, please answer the following question:
2 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Shopping cart is empty