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HEK 293 cells stably transfected with the HA-tagged human TLR2 gene
3-7 x 10e6 cells
293/hTLR2-HA cells were obtained by stable transfection of HEK293 cells with the pUNO-hTLR2-HA plasmid which expresses the human TLR2 gene fused at the 3'end to the influenza hemaglutinine (HA).
The control cell line for 293/hTLR2-HA cells is 293/null.
Antibiotic resistance: Blasticidin
Growth medium: DMEM, 4.5 g/l glucose, 2-4 mM L-glutamine, 10% (v/v) fetal bovine serum, 50 U/ml penicillin, 50 μg/ml streptomycin, 100 μg/ml Normocin™
Guaranteed mycoplasma-freeBack to the top
Shipped on dry iceBack to the top
TLR2 is involved in the recognition of a wide array of microbial molecules. TLR2 recognizes peptidoglycan, lipoteichoic acid and lipoprotein from gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast cell wall. Moreover, TLR2 participates in the recognition of some types of LPS . TLR2 is known to heterodimerize with other TLRs, a property believed to extend the range of microbial molecules that TLR2 can recognize. TLR2 cooperates with TLR6 in response to diacylated mycoplasmal lipopeptide, and associates with TLR1 to recognize triacylated lipopetides . Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14 .
1. Girard R et al., 2003. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci. 116(Pt 2):293-302.
2. Ozinsky A. et al., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A. 97(25):13766-71.
3. Lotz S. et al., 2004. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 75(3):467-77.