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293/hTLR10-HA

293/hTLR10-HA Unit size Cat. code Docs Qty Price
HEK 293 cells stably transfected with the HA-tagged human TLR10 gene
3-7 x 10e6 cells
293-htlr10ha
+-
$873.00

293/hTLR10-HA cells were obtained by stable transfection of HEK293 cells with the pUNO-hTLR10-HA plasmid which expresses the human TLR10 gene fused at the 3'end to the influenza hemaglutinine (HA).

The control cell line for 293/hTLR10-HA cells is 293/null.

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Specifications

Antibiotic resistance: blasticidin

Growth medium: DMEM, 4.5 g/l glucose, 2-4 mM L-glutamine, 10% (v/v) fetal bovine serum, 50 U/ml penicillin, 50 μg/ml streptomycin, 100 μg/ml Normocin™

Guaranteed mycoplasma-free

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Contents

Shipped on dry ice

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Description

TLR10 is the last human member of the toll-like receptor family discovered so far, and its function and direct ligand are still unknown [1]. TLR10 is preferentially expressed in lung and in B-lymphocytes. Phylogenetic analysis indicates that among all the human TLRs, TLR10 is most closely related to TLR1 and TLR6; the overall amino acid identity is 50% and 49%, respectively. These observations suggest that TLR10 is involved in the immune response like other known TLRs. TLR10 is a potential asthma candidate gene since TLR10 genetic variation were shown to contribute to asthma risk [2].

 

1. Chuang T. and RJ. Ulevitch, 2001. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta, 1518(1-2):157-61
2. Lazarus R. et al., 2004. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 170(6):594-600.

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