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2-aminopurine (2-AP) is a potent inhibitor of double-stranded RNA (dsRNA)-activated protein kinase (PKR), a critical mediator of apoptosis.
PKR is phosphorylated and activated by dsRNA and poly(I:C)  and contributes to the induction of type I interferons, such as IFN-β, which can further increase its expression .
PKR plays also a role in TLR-induced antiviral activities as an intermediary in TLR3, TLR4 and TLR9 signaling .
1.Kaufman RJ., 1999. Double-stranded RNA-activated protein kinase mediated virus-induced apoptosis: a new role for an old actor. Proc. Natl. Acad. Sci. USA 96 (21):11693-5.
2. Samuel CE., 2001. Antiviral actions of interferons. Clin Microbiol Rev. 14(4):778-809.
3. García MA. et al., 2006. Impact of Protein Kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol. Mol. Biol. Rev., 70: 1032 - 1060.
Working concentration: 1 - 10 mM
Purity: ≥ 97% UHPLC
CAS number: 452-06-2
Molecular weight: 135.1
Solubility: 20 mg/ml in phosphate-buffered saline:glacial acetic acid (200:1) with heating at 65°C for 15 minutesBack to the top
2-Aminopurine is provided as a solid.
- 250 mg 2-aminopurine
2-Aminopurine is shipped at room temperature.
Store at 4 ̊C.
Solid product is stable 1 year at 4°CBack to the top