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17-DMAG

17-DMAG Unit size Cat. code Docs Qty Price
Geldanamycin Analog - Water-Soluble
5 mg
25 mg
ant-dgl-5
+-
$193.00

Water-soluble geldanamycin analog, Alvespimycin

17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG, also known as NSC 707545) is the first water-soluble analog of 17-AAG.

This Hsp90 inhibitor shows promise in preclinical models [1]. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG [2].

Clinical studies have shown that alvespimycin (KOS-1022) has therapeutic effects and is well tolerated in patients with solid tumours, advanced solid tumours or acute myeloid leukaemia, indicating that it has potential to be a new drug of choice for cancer therapy.

 

1. Workman P., 2003. Overview: translating Hsp90 biology into Hsp90 drugs.Curr Cancer Drug Targets 3(5):297-300.
2. Egorin MJ, et al., 2002.Pharmacokinetics, tissue distribution, and metabolism of 17- (dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats. Cancer Chemother Pharmacol 49(1):7-19.

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Specifications

CAS number: 467214-21-7

Formula: C32H48N4O8, HCl

Molecular weight: 653.2

Solubility: H2O (10 mg/ml)

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Contents

  • 5 mg or 25 mg

room temperature 17-DMAG is shipped at room temperature.

store Store lyophilized product at -20°C.

Alert Protect from light.

stable Lyophilized productis stable for 6 months when stored properly.

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Citations

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