|17-DMAG||Unit size||Cat. code||Docs||Qty||Price|
Geldanamycin Analog - Water-Soluble
Water-soluble geldanamycin analog, Alvespimycin
17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG, also known as NSC 707545) is the first water-soluble analog of 17-AAG.
This Hsp90 inhibitor shows promise in preclinical models . 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG .
Clinical studies have shown that alvespimycin (KOS-1022) has therapeutic effects and is well tolerated in patients with solid tumours, advanced solid tumours or acute myeloid leukaemia, indicating that it has potential to be a new drug of choice for cancer therapy.
1. Workman P., 2003. Overview: translating Hsp90 biology into Hsp90 drugs.Curr Cancer Drug Targets 3(5):297-300.
2. Egorin MJ, et al., 2002.Pharmacokinetics, tissue distribution, and metabolism of 17- (dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats. Cancer Chemother Pharmacol 49(1):7-19.
CAS number: 467214-21-7
Formula: C32H48N4O8, HCl
Molecular weight: 653.2
Solubility: H2O (10 mg/ml)Back to the top
- 5 mg or 25 mg
17-DMAG is shipped at room temperature.
Store lyophilized product at -20°C.
Protect from light.
Lyophilized productis stable for 6 months when stored properly.Back to the top