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17-AAG

17-AAG Unit size Cat. code Docs Qty Price
Geldanamycin Analog
5 mg
25 mg
ant-agl-5
+-
$147.00

17-Allylamino-17-demethoxygeldanamycin- An Hsp90 inhibitor

17-Allylamino-17-demethoxygeldanamycin (17AAG) is a less toxic and more stable analog of geldanamycin (GA) [1].

Even though 17-AAG binding to Hsp90 is weaker than GA,17-AAG displays similar antitumor effects as GA and a better toxicity profile.

17-AAG is currently in phase I clinical trial in several centers worldwide. Preliminary data obtained from these trials demonstrate that antitumor activity is achieved at concentrations below the maximum tolerated dose [2].

 

1. Schulte TW. & neckers LM., 1998. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 42(4):273-9
2. Agnew Eb. et al. 2001. Measurement of the novel antitumor agent 17-(allylamino)-17-demethoxygeldanamycin in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 755:237-43

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Specifications

Working concentration: 10 nM - 10 μM

CAS number: 75747-14-7

Formula: C31H43N3O8

Molecular weight: 586

Solubility: Soluble in DMSO (10 mg/ml)

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Contents

  • 5 mg or 25 mg

room temperature 17-AAG is shipped at room temperature.

store Store lyophilized product at -20°C.

Alert Protect from light.

stable Lyophilized productis stable for 6 months when stored properly.

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